|
KMID : 1143420160090250482
|
|
Public Health Weekly Report
2016 Volume.9 No. 25 p.482 ~ p.486
|
|
|
Status of Global Rotavirus Surveillance Network in the Western Pacific Region of the World Health Organization, 2009-2015.
|
|
Kim Jin-Won
Jeong Hye-Sook
Yoo Jung-Sik
Lee Sang-Won
|
|
|
Abstract
|
|
|
BACKGROUND: Rotavirus (RV) caused severe gastroenteritis and resulted to 352,000?592,000 deaths in children under five years old in the year 2000. The Global Rotavirus Laboratory Network (GRLN) is a fundamental component of the World Health Organization (WHO) RV surveillance system designed to conduct high quality diagnostic testing for RV diarrhea and to characterize the most prevalent strain or genotype in different countries and regions. The Centers for Disease Control and Prevention (CDC) was designated as the WHO RV regional reference laboratory in the Western Pacific Region (WPR) in 2010. In this report, we analyzed diagnostic testing to characterize the genotypes of RV and provide quality control validation of test results from three national laboratories in the WPR.
METHODOLOGY/RESULT: From 2009, we analyzed 4,836 samples from three rotavirus national reference laboratories, i.e., Cambodia, Mongolia and Laos. Rotavirus VP4 and VP7 genotypes were characterized by semi-nested RT-PCR, first RT-PCR, and second multiplex PCR. Common human strains, P[8]G1, P[4]G2, P[8]G3 and P[8]G9, were the most prevalent in the countries mentioned. In Cambodia, the most prevalent strain was P[8]G1, P[4]G2, and P[8]G2. In Mongolia, P[8]G3 strain was the most prevalent. While, P[8]G3, P[8]G1 and P[4]G2 had a high incident rate in Laos.
CONCLUSION: Continued rotavirus surveillance provides data for establishment of policies to rotavirus prevention and development or introduction of vaccination program.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|